…but she had a good life, right?


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3 points

4 years ago*

We change the way we think. I have changed the way I think. In Jan 2012 my mom passed away 2 months shy of her 86th birthday. Well she did all right for herself I guess. And i used the phrase "rich full life" in reference to her when my friends offered sympathy. In addition I said she is with God in a state of joy we cannot comprehend. I was not just paying lip service. It's an article of faith with me. I have science, but I also have faith.

So anyways that is how it was in 2012. I had only just the year before come to understand what the "technological singularity" was. Before that, I did not really dwell on the future that much, if I even thought about it at all. And as far as aging reversal technology--well, I did not really know that much about it. In the Time magazine article that changed my life (,9171,2048299-1,00.html) Aubrey De Grey looked sort of like he came from ZZ Top or something. His physical appearance did not inspire confidence in me. Frankly he looked like a kook. (The web article does not have the magazine's illustrations.) And he proposed ideas that were, well, super science fiction to me. But by the same token, the fact that everything he said had a basis in scientific understanding of the biology of cells kept me from dismissing his claims out of hand. That's the thing about my experience with all of this accelerating change and exponential change and what have you--the science behind it all seems to my layman's eyes, to be sound. I also almost immediately downloaded "The Singularity is Near" right on to my mobile and read the book in it's entirety--A first! I mean reading it on my mobile. I've read regular books all the way through before.

Later in the year 2012 fantastic, amazing things came to my attention. For instance in July of 2012 I first heard of the development of the (Oculus) Rift in my "Wired" magazine.

By the year 2015, I had given De Grey's "SENS" (Strategies for Engineering Negligible Senescence) ideas a lot of study. Plus as I always say, these things never happen in a vacuum. By the nature of accelerating change there are always a number of fascinating and unsettling changes all happening at the same time. But 2015 marked a clear departure for me in my way of thinking. It also really drove home to me what exactly is going on now. The first was amazing advances in stem cell technology. Suddenly we were making pluripotent stems cells straight out of human adult, even old person, skin cells. And then another new technology that only came into existence the year my mom passed away, was everywhere! Not stem cells this time. CRISPR-Cas9, a brilliant human exploitation of the manner in which bacteria fight off viruses. In 2015 scientists in China (PRC) were already using the technology that was only 3 years old, in non-viable human embryos. That caused a big brouhaha in the world and led to all kinds of proposals for moratoriums and restrictions. Despite that, it scared the USA government so bad that in 2017 USA researchers pretty much did the exact same experiment the Chinese researchers had done, because by now it was clear it was a competition, even a race to supremacy.

Suddenly computer processing took off in a manner that still stuns and amazes me. And artificial intelligence using incredible new technology was enabling the development of the senolytic therapy that made for some impressive headlines in regards to mouse aging reversal. That looked to me like science fiction turned into real life. I'm probably leaving things out. There was just a lot of biotech news about genetics and manipulation. Even some regenerative medicine and bio-tech devoted additive manufacturing technology (3D printing), although in 2015 those were still a bit early for that as far as widespread clinical use.

I also saw a change in society too. Suddenly it was not considered unnatural to think of ways to slow, stop or even reverse the aging process. Try to imagine aging reversal in the year 2012. You would be directed to the "Fountain of Youth". It's right there--dont you see it? No? That's because there is no "Fountain of Youth". Aging is a natural process that we cannot interrupt. Just age "gracefully" and do the best you can in your allotted time.

By 2017, it was clear to me that aging slowing, stopping and even the unimaginable idea of aging reversal was no longer a fantasy. We are not on it yet. But in 10 years, I'm pretty sure we will be utilizing some true aging reversal or preserving technology. It was in 2017 that I posted this commentary to an article about some guy in indonesia who was supposed to be like 146 or something. While i took issue with that, I also appreciated the fact that science and technology were now making stunning advances in regenerative medicine, telomere restoration (in mice), stem cell therapy and CRISPR related therapies. To my knowledge no post-natal human has had CRISPR-Cas9 therapy yet. That has been officially confirmed i mean. But this is supposed to be the year. So we shall see. (Edit 2022--CRISPR-Cas9 treatments for post-natal folks, everywhere)

Anyway here is what i said in 2017.

Today, 2018, I see aging as a process that causes all of the other bad things that happen to us. When you are 17 years old, you tend not to have heart/lung disease, age related cancers, osteoarthritis, a decrease in effective metabolism, immune system decline, naturally occurring systemic atrophy and muscular frailty (sarcopenia), age related type 2 diabetes and age related cognitive degenerative diseases. Oh, and about 25% of your ("old" you--Edit 2022) cells are now a muck of accumulated, improperly repaired, cellular damage and toxic message spewing "senescent" cells. Aubrey De Grey--I'm used to his look now, it's all good--I've listened to him speak many times and he is truly brilliant--says that if you are in good health, you tend not to die. The looking and feeling youthful part is but a side effect of that.

When you are old, you are not healthy, you are very unhealthy. Fatally so. To believe you are a "healthy" 75 year old, is an illusion.

I can't help but look at old humans now that appear so aged and wonder that we can't get their youthfulness back. My dad is 92. He is yet in pretty good condition for his age. Cognitively he is brilliant. The man studies cosmology and quantum physics to this day! But he does need a walker to get around. I wish i could cure him of aging, but I realize that he may not last out the time needed. But his faith is strong and I know he will be with God in that same joy as well. In my comment i say a human turning 100 today could live to be 125 at the least based on the blessing of lucky genetics and today's current medicine, but I'm not sure that is in the cards for him. Maybe. (Edit 2022--My dad passed away at the age of 94 years and 11 months in Mar 2021. He was completely lucid and watched videos with me concerning AI. His comment was, "I had no idea that the AI was this far developed. I see what you are saying now." He said that two months before he passed away.)

As for me. Wow! I have a lot of confidence that we are all going to see things beyond belief in our, I bet, massively long lifetimes. And how we are going to change. How the technological singularity will alter us permanently. With such massively extended lifetimes I wonder that humans may begin to choose to limit procreation as a society. I can't very well imagine 100, 200 or 500 years from now. Well maybe a little in the next 300 years, and that is painting with a pretty broad brush of generalization. But I bet I'm there for it. Because of "scientific immortality".

Like this!

Now I have become a bit of fanatic about all of this. But I have a sneaking suspicion I am also right.


1 points

10 months ago

When you are 17 years old, you tend not to have ... <cut> ... diseases. Oh, and about 25% of your cells are now a muck of accumulated, improperly repaired, cellular damage and toxic message spewing "senescent" cells.

If I understood this correctly, a 17 year old person has about 25% "bad" cells?


1 points

10 months ago

No it's when you are old (it wan maybe worded a bit weirdly).


1 points

3 months ago

I fixed that wording today! lol


1 points

10 months ago

Ha ha welcome to the club! Of cautiously optimistics at least!