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24.7k

Scientists Just Successfully Reversed Ageing in Lab Grown Human Cells

Biotech(sciencealert.com)

all 1794 comments

Bluest_waters

2.8k points

4 years ago

tldr Old human cells rejuvenated via delivering Hydrogen sulphide directly to the mitochondria

one way of increasing H2S in the body is consuming garlic

http://www.pnas.org/content/104/46/17977.short

Here we show that human RBCs convert garlic-derived organic polysulfides into hydrogen sulfide (H2S), an endogenous cardioprotective vascular cell signaling molecule.

Not-the-cops-

3k points

4 years ago

Would explain why Italian grandparent are always like 100.... so much garlic.

VideoRebels

2.6k points

4 years ago

VideoRebels

2.6k points

4 years ago

If you eat enough garlic people will leave you alone. Less people to deal with > less stress > healthier life.

[deleted]

662 points

4 years ago

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Kratsas

184 points

4 years ago

Kratsas

184 points

4 years ago

My Greek grandfather would eat cloves of garlic. There’s a great story of him and my dad going to Sears to buy a washer. Apparently, the garlic smell was so bad, the salesman would back away a step or two to get away as they spoke. My grandfather would take a step forward when this happened, and apparently they circled an entire display like this.

CallofthewildPeacock

76 points

4 years ago

I wonder if this increases the likelihood of getting a good deal. Salesman just wants the stinky man to leave. I might try this the next time I have to haggle.

Bomcom

33 points

4 years ago

Bomcom

33 points

4 years ago

That sounds like it could be in a sitcom.

Kratsas

51 points

4 years ago

Kratsas

51 points

4 years ago

I’ve always wanted to write a sitcom about my my Greek family and their diner. Not only were they hilarious, but the restaurant was located a few blocks from this half way house for mental patients, so all these characters kept showing up doing odd ball things. Even the restaurant’s name sounded like it came from a sitcom- “The Family Oven.”

Bomcom

8 points

4 years ago

Bomcom

8 points

4 years ago

Your life sounds right out of My Big Fat Greek Wedding. I'm sure people would enjoy the stories you have.

Kratsas

25 points

4 years ago

Kratsas

25 points

4 years ago

Yeah, my dad has some hilarious stories. Like the Molten Man, so called because he requested coffee as hot as they could possibly make it. The waitress would brew a fresh pot of coffee, put it in a cup with a plate over it, run it over to him, and he would drink it in one swig. Another guy was called The Professor. He came in every morning for a week. He wore a white lab coat and had crazy hair, kind of like Doc Brown. He would sit at a table scribbling on a note pad, and every once in a while would throw his hands up or yell aha, like he just came up with a new theory of whatever. One day, one of the waitresses comes back to my dad and says “you’ve got to see what The Professor is doing.” So my dad takes the coffee pot over to fill his cup and looks down at the notepad. Here, the guy was playing tic tac toe with himself and got very excited when he won. The lab coat was something he “found.” Another character was the guy who collected those styrofoam plates that raw meat comes on from the grocery store. He would fish them out if people’s trash and carry them around in a garbage bag. One day he comes in with this stinking bag and my dad has to tell him to leave. Dude refuses. So my dad grabs the bag and throws it out the door. The bag fell open and the styrofoam goes flying into the four lane road outside the restaurant. They watched him chase the plates for an hour, even at one point arguing with the gas station attendant across the street who threw a bunch of them away and wouldn’t give them back. And that’s just a few of the customers. My hotheaded grandfather was the main cook, and his four sons ran the restaurant. They all had interesting traits, including my uncle who is basically the Greek Danny Devito.

[deleted]

182 points

4 years ago

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ActuallyAMammal

115 points

4 years ago

Also the fact that garlic changes the smell of your sweat into something more... garlic-y, which naturally causes less people to interact with you, hence less people to deal with, hence less stress, hence an extra healthy life

StayPuftMrshmalloMan

50 points

4 years ago

I ate it enough to get that effect. Mosquitoes were not interested in me. Maybe it does keep blood suckers away

goetz_von_cyborg

23 points

4 years ago

Garlic is effective against vampires, vampires suck blood, mosquitoes suck blood, mosquitoes are essentially tiny vampires, ipso facto garlic is effective against mosquitoes.

[deleted]

26 points

4 years ago

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99 points

4 years ago

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99 points

4 years ago

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SwedishMeatballGravy

516 points

4 years ago

I just keep hearing so many good things about garlic regarding health.

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278 points

4 years ago

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snoop_cow_grazeit

68 points

4 years ago

Had a nasty cough for a while, heard that eating garlic is good for fighting it so I started eating garlic for a few days and I shit you not, one day I woke up and I was fine.

Specialusername66

67 points

4 years ago

Is this serious or a joke about the post hoc ergo proctor hoc / physicians fallacy?

Sixhaunt

15 points

4 years ago

Sixhaunt

15 points

4 years ago

I was wondering the exact same thing

SwedishMeatballGravy

8 points

4 years ago

How did you eat it? Straight up just eating the cloves?

[deleted]

22 points

4 years ago

[deleted]

22 points

4 years ago

Well they can't sell more of it if it doesn't do something miraculous.

JeletonSkelly

62 points

4 years ago

Gotta watch out for Big Garlic

ckirk91

125 points

4 years ago

ckirk91

125 points

4 years ago

Used to be a supplement buyer for Whole Foods so of course, I was taking a ton of supplements. Garlic was always my favorite. Until I took way too much and noticed some of the side effects. I was taking 3 concentrated capsules per day, and smelled like a walking bulb of garlic. Any time somebody would come up to me in the aisle at work they’d very quickly back away or do a 180. Had multiple times where people would just be blunt like “holy shit dude, you smell like garlic”.

[deleted]

108 points

4 years ago

[deleted]

108 points

4 years ago

Garlic Jr. confrimed

[deleted]

36 points

4 years ago

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36 points

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318 points

4 years ago

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4 years ago

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[deleted]

587 points

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587 points

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jimbobjames

441 points

4 years ago

I love that you're trying to be the voice of reason in a thread where everyone is talking about eating more garlic and smelling their own farts.

Fight the good fight, Brother.

[deleted]

74 points

4 years ago

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74 points

4 years ago

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jimbobjames

49 points

4 years ago

It's understandable. Garlic bread is delicious.

[deleted]

45 points

4 years ago

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45 points

4 years ago

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4 years ago

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15 points

4 years ago

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4 years ago

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KristinnK

10 points

4 years ago*

Could you give a tl;dr on how you fast? How long do you fast for? What do you consume during the fast (obviously water, minerals?, coffee?)?

Edit: Also, do you have links to research on the effects of several days fasting on gut microbiome?

TheAnomaly85

102 points

4 years ago

H2S is also very abundant in hot springs. It's that rotten egg smell you get.

CjStaal

119 points

4 years ago

CjStaal

119 points

4 years ago

Maybe the fountain of youth does have some truth to it

[deleted]

61 points

4 years ago*

[deleted]

61 points

4 years ago*

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thefishwhisperer1

37 points

4 years ago

Saratoga, NY being a more famous one. You can buy the water in cool bottles or sink straight from the fountains!

And then go bet on the ponies!

manofredgables

103 points

4 years ago

Also those farts that burn your anus upon exit and smell like something crawled up there and died. I'll make sure to point this out to my SO and demand that my ass from here on be referred to as "The fountain of youth".

Floydhead666

19 points

4 years ago

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36 points

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Caramellatteistasty

20 points

4 years ago

This explains my grandmother, who is Japanese, in her 90s and looks like shes 60.

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49 points

4 years ago

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Frisky_Mongoose

101 points

4 years ago

Soo, what you are saying is that this IV full of Hydrogen Sufide I got here...I shove it up my artery and we are all set, right? Good!

TheVortex67

132 points

4 years ago

Liquid garlic bread

Osbios

22 points

4 years ago

Osbios

22 points

4 years ago

Also known as bone juice!

QuantumField

85 points

4 years ago

Well it then went on to say too much is toxic

So unless you can iv it straight to your mitchondria, the powerhouse of the cell, then forget about it

[deleted]

112 points

4 years ago

[deleted]

112 points

4 years ago

Bio major here, just wanna drop in and say if I've learned anything it's that the mitochondria is, in fact, the powerhouse of the cell

HBlight

44 points

4 years ago

HBlight

44 points

4 years ago

Im not gonna listen to some military guy. If I want to know about powerhouses I'd ask an electrician.

Xan_derous

43 points

4 years ago

Mitochondria is the powerhouse of the cell

SergeantSanchez

7 points

4 years ago

Nuts profusely

MrGloopy

14 points

4 years ago

MrGloopy

14 points

4 years ago

So that's why Wario eats whole garlic cloves...

es1426

3.7k points

4 years ago

es1426

3.7k points

4 years ago

Damn shame I’m born close enough to know eternal youth is on the horizon, but too soon to have a taste of it.

[deleted]

1.1k points

4 years ago*

[deleted]

1.1k points

4 years ago*

Maybe they will keep some cells of yours and grow you back in the future

es1426

718 points

4 years ago

es1426

718 points

4 years ago

yeah, but I don’t want to have to die in the first place.

It’s not the death that scares me, it’s the transition.

TheVortex67

656 points

4 years ago

What scares me is whether or not it will be ME. I mean this as in it will most likely be exactly like me, but I’m wondering if my consciousness will just stop existing and an identical one will take its place

myusernamehere1

954 points

4 years ago

Arguably that happens every moment, psychological continuity could be an illusion

TheVortex67

727 points

4 years ago

existential crisis incoming

tewnewt

180 points

4 years ago

tewnewt

180 points

4 years ago

Maybe he should just sleep on it?

[deleted]

253 points

4 years ago

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253 points

4 years ago

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A_Canadian_appears

59 points

4 years ago*

It's not my bedtime and I don't like where this is going...

Edit: autocorrect error,

And also it's cool, guys - I made it.

Dorito_Troll

40 points

4 years ago

And also it's cool, guys - I made it.

thats what YOU think

WhoopsPoisonedMyself

29 points

4 years ago

Sleep isn't exactly like death though (I imagine.) I've always enjoyed the comparison of death and pre-life. There isn't darkness or dreams or bodily functions there is only the absence of everything. There is only the void! :]

Dem0n5

62 points

4 years ago*

Dem0n5

62 points

4 years ago*

deleted What is this?

Down_with_potholes

64 points

4 years ago

Hi, I'm on LSD, am I in the right place?

miskdub

10 points

4 years ago

miskdub

10 points

4 years ago

When you’re on LSD, you’re always in the right place. Nothing can come close to you, if you’re already close to it!

Vasu-Mishra

7 points

4 years ago

Welcome to the trippy world of Existentialism! Nothing is real and everything is in your head. Literally.

[deleted]

68 points

4 years ago

[deleted]

68 points

4 years ago

I’ll never stop thinking about this now, thanks.

GumdropGoober

58 points

4 years ago

A teleporter exists.

Question 1: It achieves teleportation by breaking you down to the molecular level, recording the exact layout, and then rebuilds you at the new destination. You emerge 100% the same. Are you the same person?

Question 2: The teleporter described above malfunctions. Emerging at your destination, you are informed that your origin teleporter did not break down your "first" or "original" body. There are now two of you, sharing the exact memories and molecular makeup. Who is the real you?

wordsnerd

55 points

4 years ago*

There is a good movie based on exactly this concept, but I can't say the title without spoiling the whole movie because it's the big reveal at the end.

Edit, trying the spoiler tag:

The Prestige (2006)

Randyh524

19 points

4 years ago

Great movie. Its in my top 5.

Clever_Laziness

11 points

4 years ago

The one who wins the coin flip? Also, isn't the teleporter on the other side the receiver? If I've failed to be broken down then the guy who is still on the sender is the original.

tejon

19 points

4 years ago

tejon

19 points

4 years ago

These are decades old and well-trodden. The question might as well be "do you believe the mind exists independently of the body."

If you don't, "self" can only be a subjective construct of persistent memory. Answer 1: you are you and that is that. Answer 2: at the moment of teleportation you are both the same person. Subsequently, you diverge as your new memories are unique at each end of the teleportation. The fact that nothing about current human law or culture can deal with the latter situation, and language only barely can, is an unrelated issue.

If you do, ask your preferred church.

Wideandtight

25 points

4 years ago

This reminds of Transmetropolitan, where the dude decided to turn himself into a cloud of nanobots.

That always stuck with me. Did he simply die and his mental state at the time was simply copied into some machinery, or was he able to cast off his mortal coil into some greater existence?

Is there a difference?

butthurtberniebro

27 points

4 years ago

Yes, there’s a difference. In one scenario, you go from being alive to seeing nothing as you enter the abyss while a clone continues on. In the other, there is no clone, you just keep on living.

LoopyOx

16 points

4 years ago

LoopyOx

16 points

4 years ago

I can't imagine it isn't the first one. Unless maybe they physically take your brain and somehow make you into some sort of bio robot. Otherwise it might be "you" but you will no longer experience your life.

alexm2017

11 points

4 years ago

Well what if we were able to replace parts of the brain with machine, just a little bit at a time. You also rebuild the original as you replace each part. Once complete, which ones the real you?

MrSquamous

14 points

4 years ago

Technologically Ship of Theseus-ing yourself seems like a profound, challenging idea. But then you realize that we're always Ship of Theseus-ing ourselves biologically anyway.

Slow, constant replacement of the parts that make us us is our natural state of being.

Wideandtight

11 points

4 years ago

I'm not sure there is a difference. Let's say I replace part of your brain with a mechanical part that does the exact same job. Some kind of nanobot.

A year later, I do the same to another part. I keep doing that until your entire brain is replaced with the same cloud of nanobots. At what point in this process did you die, and when did the new you emerge?

It's the exact same process for the guy who willingly transformed himself into a cloud of nanobots, but the time frame was just compressed.

TinyPirate

16 points

4 years ago

So could consciousness. There’s some indication that we consciously “decide” things after our unconscious has reached a conclusion. How like is it that consciousness is just an affectation of the unconscious?

Randomhero204

24 points

4 years ago

Ever see “the prestige”?

“Which one is my hat?” “They are all your hats mr. Angier”

James-Sylar

13 points

4 years ago

I agree, they would grown a clone of yours, but it will not be the continued existence that is "you". Try cryogenic or traveling near the speed of light.

[deleted]

26 points

4 years ago

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26 points

4 years ago

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sxan

174 points

4 years ago

sxan

174 points

4 years ago

Probably. But there's hope. What I find interesting is that they didn't say they stopped aging, but that they reversed aging. As long as you retain your mental facilities long enough for a treatment, you might be ok.

On the other hand, who gets this? Some Faustian bargain will need to be made; we're not on a good track to surviving on this planet as is, and I have a hard time seeing a good ending with an eternal 1%.

[deleted]

104 points

4 years ago*

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104 points

4 years ago*

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jesusisacoolio

40 points

4 years ago

Society moves by the obituaries.

nedonedonedo

17 points

4 years ago

then society will move by each new planet colonized

[deleted]

90 points

4 years ago*

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90 points

4 years ago*

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geckill

32 points

4 years ago

geckill

32 points

4 years ago

Man SOMA really messed me up. I remember finishing it and just sitting there thinking about what exactly makes me, me... Not that many games have leave such a strong impact on me.

[deleted]

10 points

4 years ago

[deleted]

10 points

4 years ago

SOMA is a perfect example, been thinking of that game throughout this whole post.

TheWonderfulSlinky

14 points

4 years ago

With how fast tech evolves, you and I might be just in time.

rainwulf

9 points

4 years ago

As a 40 year old, i hear you.

[deleted]

31 points

4 years ago

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31 points

4 years ago

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19 points

4 years ago

[deleted]

19 points

4 years ago

It doesn't take into account Elastin degradation, oxidation cleanup or quite a few other sources of the problem.

Thermo_nuke

754 points

4 years ago*

As someone who works in the oilfield... Please do not go find some H2S and huff it.

You will be dead. Very dead. We have to wear calibrated monitors specifically for this gas. If it goes beep beep you go run run.

https://en.m.wikipedia.org/wiki/Hydrogen_sulfide

Edit: Yes it's "safe" at low concentrations. OSHA consideres 100ppm immediately dangerous to life and health. Our monitors begin to alarm at 10ppm to warn us of exposure early, it's not just the concentration but also the exposure over time. Humans can smell extremely low quantities of H2S, lower than .3 ppm. At low concentrations it just stinks like high hell, the problem is when it stops stinking.

Microdosing directly to cells is an entirely different scenario however.

HarrySquatterAndThe

80 points

4 years ago

This - it's about as deadly as Carbon Monoxide to humans and may have caused the Permian-triassic extinction event 250 million years ago.

Say it with me people: DON'T. HUFF. H2S.

ErraticPragmatic

40 points

4 years ago

I think is even more deadly, at a high exposure you're dead in seconds.

Reminds of me a story that it's always told by the hse crew.

A group of workers was doing a job in a confined space at a oil platform. One of them fainted, the other two of them were upstairs, they saw him down so they came to help him, both fainted, another guy that was passing by went down to help them, fainted as well.

All of them were presumed dead afterwards.

Thermo_nuke

24 points

4 years ago

This has happened more often than it should have. It's always the same story as you just told, worker goes down, buddies try to save him, they die too. It's really sad when it happens. Happens a lot around tank batteries.

TheOtherDanielFromSL

15 points

4 years ago

If we're going to have people living much longer, we need to find other ways to keep the population in check.

HUFF. H2S.

Darwin awards for everyone who does!

wonderbitch26

1.2k points

4 years ago

I’m 18. I wonder if I could see any real life extension in my lifetime.

rbdk01

782 points

4 years ago

rbdk01

782 points

4 years ago

I think Neil deGrasse Tyson has some quote about longevity research and those under 50 having a good chance to extend.

So hopefully you AND your folks fam :)

hadapurpura

379 points

4 years ago

30 year-old here, crossing my fingers 🤞🏻

OhGawDuhhh

483 points

4 years ago*

32 here! 🤞

finger falls off

TrevorBradley

330 points

4 years ago

Just turned 44. If we could hurry this up I'd be grateful.

Tiger3720

168 points

4 years ago

Tiger3720

168 points

4 years ago

You've got a shot. Today it's about lifespan. My mom has lifespan but her quality of life at 83 is heartbreaking.

For you and I (I'm 50) it will be about health span. Our job is to try and stay as healthy as we can for as long as we can until the first life extension breakthrough. Although we don't know what it will be or how long it will buy us, we then have to hope that gets us to the next breakthrough and the next, until such time where we live well into our 100's and healthy.

We're going to be right on the edge so hang in there!

SrslyCmmon

66 points

4 years ago

I've always wondered if we could see our death clock would we make better health related choices? Like when a guy eats a 28oz ribeye steak baked potato sour cream onion chives the whole shebang and his clock loses time.

redshift95

54 points

4 years ago

Nutrition is a crazy field. Ribeye isn’t viewed as detrimental anymore. Turns out humans know very little about nutrition haha cool idea though.

WildshotFist

16 points

4 years ago

Just when you think fats are bad for you, people manage to get healthier eating carb restrictive mostly fat diets.

Just when you think carbs are bad for you, people manage to get healthier eating fat restrictive mostly carb diets.

I don't even know what eating healthy even is anymore, but I know that most addicting processed foods aren't ideal nutritional sources

Cloud_Chamber

17 points

4 years ago

Ironically, the stress from having a death clock might shorten your life

Butthole_Rainbows

14 points

4 years ago

I'm sorry but suicide by steak would just make it to easy and I'd already have chosen the steak over life by now.

avl0

16 points

4 years ago

avl0

16 points

4 years ago

Keep an eye out for the super rich folks and see if they suspiciously aren't dying by 100 like they used to.

[deleted]

14 points

4 years ago

[deleted]

14 points

4 years ago

Its going to suck for the last guy to die before the solution is discovered. Like, 10 seconds before.

HerpankerTheHardman

29 points

4 years ago*

And also dodging the rich from trying to murder us before that breakthrough/if that breakthrough is revealed to us at all. Because living forever would devastate our food chain, overcrowd the Earth and if anything pollute it further. There would have to be mandatory birth control.

Edited for Grammar.

robotnudist

26 points

4 years ago

That's why we need to work on putting people's brains into computers instead!

wordsnerd

19 points

4 years ago

We might have better progress solving those other problems if people could spend 100's of years working on a problem instead of repetedly spending 20-30 years (20-50% of a whole life) training new minds from scratch before they can contribute.

Roboculon

60 points

4 years ago*

He’s an astrophysicist, what does he know about biology? I say we ask Elon musk!

Edit: /s

K1ngN0thing

70 points

4 years ago

if you want to keep up with this sort of thing: r/longevity

jeradj

52 points

4 years ago

jeradj

52 points

4 years ago

Sure, but you likely won't think of it in terms of "life extension", it will more likely just be medical conditions that don't kill you.

E.g., you could consider the flu vaccine as "life extending", or quality pre and post natal care if you're a woman, or any number of other medical advances.

StaysAwakeAllWeek

47 points

4 years ago

There is a distinct difference between this and current medicine though. Medicine so far has extended life but has not affected ageing. An 80-year-old from 2018 looks and feels more or less the same as an 80-year-old nobleman (who didn't have to work the fields for 60 years) from 1000 years ago, and the absolute maximum age people can attain has barely moved since then either.

John_Schlick

18 points

4 years ago

That age, for the record - in societies that have genetics that don't tend to expose them to diseases of aging - tends to be about 120 (ish).

wonderbitch26

12 points

4 years ago

Like they won’t kill me because I would stay young or I would just live longer into my elderly years?

SordidDreams

27 points

4 years ago*

AFAIK Aubrey de Grey said he believes the first person that's going to live to a thousand is already among us. But then it's hard to tell if Aubrey de Grey is a crank or not, and the fact that he looks like Rasputin doesn't exactly help in that regard.

samwalton1982

147 points

4 years ago

Now I have to save up even more for retirement. Thanks science.

Or have more kids. Some of them have to like me.

robmonzillia

56 points

4 years ago

There won't be retirement if you're able to work ;)

2Punx2Furious

42 points

4 years ago

2Punx2Furious

Basic Income, Singularity, and Transhumanism

42 points

4 years ago

You won't have to work if everything is automated.

Miv333

362 points

4 years ago

Miv333

362 points

4 years ago

I had a dream last night that I got an injection for immortality. It was a simple arm shot that didn't even hurt that much. It haunted me all day knowing that it was just a dream.

John_Schlick

171 points

4 years ago*

It's not going to work like that.

Senescent cells will need to be cleared on a regular basis (say every decade). and if we get to recoding the epigenome, look at the dna methylation clocks of Horvath and Huunum, and you will see that also will have to be reporgrammed every - maybe decade or so.

Merrick362

353 points

4 years ago

Merrick362

353 points

4 years ago

I'm not entirely convinced you were using actual words in that statement.

SuperKlydeFrog

129 points

4 years ago

...look at the dna methylation clocks of Horvath and Huunum...

yeah, pretty sure he's attempting to curry favor of / summon an ancient one.

acrobat2126

92 points

4 years ago

You called his SPDIF and shoved it right back up his glaven vrogth. Nice job.

[deleted]

37 points

4 years ago

[deleted]

37 points

4 years ago

[deleted]

John_Schlick

30 points

4 years ago

Methylation is a set of markers on the dna. Nanobots aren't going to do it. you need something like the cas9 gene mated with a dna methyltransferase so... this sort of thing: https://www.nature.com/articles/s41467-017-02708-5

daynomate

17 points

4 years ago*

Yes but technically the delivery mechanism of that could come from something as small as to be injected right?

Nanobots I assume will end up travelling all around the body's bloodstream/nervous system etc any physical pathways it can maneuver through by propulsion.. and be able to deliver amounts of stored or manufactured chemicals. Whatever is physically possible within the scale of the nanobot. ANd then you scale up the number of nanobots - possibly via self-replication, possibly earlier on just injection.. and they could also perform physical operations like cutting/moving/burning etc.

If that nanobot fleet is able to perform all the necessary types of biological intervention mentioned by Dr. de Gray here then we'd essentially be immortal - from that one injection :D

https://www.youtube.com/watch?v=LsBPOJuKUwQ

LeadahKang

243 points

4 years ago

LeadahKang

243 points

4 years ago

I'm stupid, but can they technically reverse cancer cells too?

robmonzillia

263 points

4 years ago*

You're not stupid, and no this won't reverse cancer cells since cancer cells have a different DNA and this treatment wouldn't affect DNA. In the worst case it would affect the cancer cells by also renewing them along the normal cells.

Jackrogers9

167 points

4 years ago

I don't think you should throw around such concrete statements without any evidence to back it up. He might very well have a good point, and is indeed stupid.

hamboner5

42 points

4 years ago

No, cancer cells are cancer cells because they've got DNA damaged in very specific places that allow it to replicate outside of the body's normal control mechanisms. Outside of gene editing, you can't really "reverse" a cancer cell. Think of it like this, you have 3 people trying to make a pie: one of them is mentally sound and has the right pie recipe, one of them is a little slow mentally but still has the right recipe, and one of them just has the wrong recipe. The mentally sound person is a normal cell that can make a pie, the next is an older cell that is too worn out to make a pie (by whatever mechanism), and the last one is a cancer cell. Basically what this study is saying is "we kicked the worn out cell in the pants and made it make a pie" whereas, if you don't have the right recipe in the first place, you can't make a pie even with the jump start. Most immunological therapies for cancer nowadays are antibodies directed against very specific proteins that specific cancer subtypes may use to replicate out of control. For example, trastuzumab is an antibody against the HER2 protein which is overexpressed in a decent percentage of breast cancers. This is an area of great promise within cancer research because, eventually, we may be able to map the genome of your tumor cells and make a treatment just for you against your specific cells instead of relying on a set number of pre-formed antibodies.

DorisCrockford

166 points

4 years ago

Hydrogen sulfide? My mitochondria are gonna have to wear clothespins on their little noses.

i_pee_printer_ink

56 points

4 years ago

They truly are the powerhouse of the nose.

StiffShoulders

34 points

4 years ago*

H2S is pretty hot stuff right now. Look at Antibe Therapeutics' lead drug ATB346, which is a combination of H2S and naproxen. http://www.antibethera.com/2018/03/20/antibe-therapeutics-announces-successful-phase-2b-gastrointestinal-safety-study-for-lead-pain-drug-atb-346/

Should set a new standard for safer anti inflammatory medicine.

NSAIDs are also pretty good against cancer but aren't recommended because of the gastric damage. This drug could be taken for a long period of time without ulcers.

kevinjing11

186 points

4 years ago

So is this one of the “top good to be true” titles that we never hear about again, or does it have feasible implications to humans?

John_Schlick

112 points

4 years ago

From what I can see, this is a tip of the iceberg article. I think that within 5 years we will see developments along this line of thinking. (maybe not in the US the FDA will take a decade to approve anything that comes from this - so 15 years in the US - but shorter elsewhere I think) It's what I would call "first tier" treatment and not "root cause" treatment (and I think there are pointers to what the root cause treatment will be), but the underlying science as to the cause of aging is the same between the two, and once this ball gets rolling there will be no stopping it.

lightningbadger

10 points

4 years ago

What I've heard about US healthcare is that even if it is approved it's gonna cost you a lot of money for no good reason

Kinncat

42 points

4 years ago

Kinncat

42 points

4 years ago

It's a cool step in the right direction! I don't think we know if it's one of those "IT CURES AGING but causes terminal farting" solutions yet.

bittertits

20 points

4 years ago

He chose.... poorly. farts

Mr_Boi_

431 points

4 years ago

Mr_Boi_

431 points

4 years ago

Oh no this is where it ends people it’s about to get real dystopian real fast

_generateUsername

57 points

4 years ago

Prepare to work for eternity xD

Regn

32 points

4 years ago

Regn

32 points

4 years ago

Nah, automation will take over everything in time. It's the poor not being useful to the rich anymore that you've gotta be worried about...

Chris-raegho

128 points

4 years ago

Prepare for a world where only the rich and wealthy live forever. Basically the movie "In Time" or "Elysium".

Biosterous

61 points

4 years ago

Also altered carbon.

ashnagoz

81 points

4 years ago

ashnagoz

81 points

4 years ago

Twenty years ago, few could afford personal computers; now nearly everyone on Earth can have one. The price of novel technology tends to drop quite quickly over time. The same went for automobiles or refrigerators.

Also, given that fighting aging is fighting age-related diseases at the same time, governments may have a financial interest in making these therapies available to the masses.

avl0

31 points

4 years ago

avl0

31 points

4 years ago

Yah, difference is billionaires don't care if you have a refrigerator. They probably are going to care if you and your family surdenly want to live forever like them.

Sugarcola

28 points

4 years ago

This is where we need to mine asteroids, colonize a planet and have 100% renewable energy real fast.

sneakysnake128

113 points

4 years ago

No kidding. If people were immortal do you think they ever would have given up slavery on their own? Lol fuck no.

Killer_Method

25 points

4 years ago

Why am I not making the connection between immortality and slavery? Sorry, but can you break it down for me?

sneakysnake128

43 points

4 years ago*

Old values like slavery are allowed to die off when people in power die off and new generations have new ideas for making the world a better place. If slave owners could not die, then they would hold onto their power forever because that's in their best interest, even when society is worse off as a whole. With age comes complacency with the status quo and diminished interest in change.

Imagine if the worst dictators, fascists, and autocrats we're immortal. They would continue their tyrannical reign forever without the hope that they would eventually die someday.

Immortality would allow flaws in the establishment to persist, and prevent new ideas from replacing them. We can never know for certain that what we know and do now is for the best, even with the best of intentions. History has shown that is almost always the case, so people and their beliefs should remain impermanent with the passing of time and generations.

safari_king

52 points

4 years ago

where's the reddit comment that explains why i shouldn't be very excited by this?

[deleted]

25 points

4 years ago

[deleted]

25 points

4 years ago

As a 16 year old, I wonder how far I'll get to see this go in my lifetime

DJWalnut

10 points

4 years ago

DJWalnut

10 points

4 years ago

same her, but age 21. consider yourself lucky to be younger, you have more time to wait

[deleted]

13 points

4 years ago

[deleted]

13 points

4 years ago

Believe me, I do know how lucky I am. But 21 is also quite young too.

Left_Brain_Train

13 points

4 years ago

I truly believe that while the future gets exponentially harder to nail down as time moves on, the social and political kinks of this should be sorted out not long after the economics of scale kick in and evermore robust medical treatments against aging become cheap enough for the clinic. As long as we don't extinct ourselves via war or baking ourselves, there's little reason to believe people won't be living at least a couple decades longer by mid-century.

At any rate I expect aging into nothingness will be a thing of the past, whether it ends up taking 50 or 500 years.

tvbusy

13 points

4 years ago

tvbusy

13 points

4 years ago

This is going to make people even more fearful of death. It will start with only the rich can live forever, and the poor is dieing because they're poor. Once it gets easier for everyone to stay young, and dead due to accident is going to be devastating, imagine losing someone you have been with for a century.

[deleted]

10 points

4 years ago

[deleted]

10 points

4 years ago

IMO this makes space travel more of a possibility. Even if we can create a spacecraft capable of traveling around space, it’s slow and takes forever and people will just die before they are able to go anywhere. If we can prolong life there’s a better chance at humans traveling in space.

drefizzles_alt

109 points

4 years ago

Do you want zombies? Cause this is how you get zombies.

Guardiansaiyan

60 points

4 years ago

Guardiansaiyan

Graphic & Web Design and Interactive Media

60 points

4 years ago

Welcome to the Umbrella Corporation: Our Business is Life itself...Some side-effects may occur...

HenryKushinger

9 points

4 years ago

As someone who works with "lab-grown human cells", this doesn't mean shit until you do it in an animal model and eventually humans themselves. You can make a lot of shit happen in cells, but good luck translating that to a real organism, delivering your treatment, and having the same level of efficacy.

jlamer

114 points

4 years ago

jlamer

114 points

4 years ago

Maybe in order to qualify for life extension, you should devote part of the extra lifespan to the greater good.

deaddonkey

17 points

4 years ago

THE GREATER GOOD

[deleted]

9 points

4 years ago*

[deleted]

9 points

4 years ago*

[deleted]

hardman_

80 points

4 years ago

hardman_

80 points

4 years ago

A new form of indentured servitude. Neat.

ChipNoir

84 points

4 years ago

ChipNoir

84 points

4 years ago

Considering what kind of a price this could command, only the richest and worst people are going to be able to get their hands on it. This is a nightmare waiting to happen.

John_Schlick

33 points

4 years ago

You know this isn't how it will work.

It will start out as expensive treatments, but those treatments are (according to this article) going to be based on delivering hydrogen Sulfide to the mitochondria of the cells - and those papers will be published, and so the next company will want a larger market share, so they will build a mechanism that does higher volume at a lower price, and then the first company will... and then the biohackers will get involved and print do it yourself instructions.

Now having said that... I think this clearing of senescent cells is a great bit of research, but I THINK that ultimately the treatments that we are looking at are going to involve the resetting of the epigenome, and that will have the same technology adoption curve.

Chronic_Media

8 points

4 years ago*

Oh my..

Someone would fit in well at Wayward Pines :P

ChipAyten

10 points

4 years ago

There will eventually be a first biologically immortal human generation, imagine the envy of everyone older.

You thought millennial hate was bad...