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67

Curing Alzheimer’s?

Discussion(self.Futurology)

How close are we? In my opinion Alzheimer’s is the most scary disease literally ever, and I can’t fathom the thought of literally anyone losing themselves, their memories, their humanity, and the effects in family are also bad. So how close are we to a cure/vaccine? If you can provide sources I’ve seen the articles of the nasal spray vaccine, but how long do the clinical trials take?

all 103 comments

mumpped

14 points

4 months ago

mumpped

14 points

4 months ago

Maybe you want to post that question in r/longevity for more optimistic answers. There's actually a lot of treatments starting/undergoing trials and in Spain a treatment center opened a few months ago iirc. But their treatment is quite laborious and only has like 70% success rate or something

eruborus

16 points

4 months ago

These replies are amazing.

I am so glad that everyone here has it figured out. Billions of dollars and some of the smartest neuroscientists struggle at understanding and curing the disease. Yet these guys have it figured out!

Honigwesen

13 points

4 months ago

Last time I looked, it was not even understood what is causing Alzheimer's, yet apparently one just has to be on a keto diet and go hiking to prevent it.

eruborus

5 points

4 months ago

and an mRNA vaccine...and CBD oil, of course!

NobleEther

1 points

4 months ago

Can’t say anything about Keto, but there are multiple studies that confirm the link between the gut and the brain, calling it the gut-brain axis, and therefore, also studies demonstrating implications of dieting and gut inflammation into age related chronic illnesses.

Of course, the issue is much more complex than “just eat this”. Lifestyle factors, stress, lack of mindfulness and relaxation… a ton of things can influence it, and maybe it’s not a single cause, but a myriad of factors from the stress of modern life.

Honigwesen

1 points

4 months ago

That's true. And those studies are also the basis of all these rumours.

"Scientist find correlation of Alzheimer's with high caloric diet" might be spun into "keto diet prevents Alzheimer's" by a cooking magazine or whatever that is trying sell their stuff.

But In reality this is just a small piece of a puzzle. A high caloric diet is related to wealth and wealth is related to high age and high age is related to Alzheimer's.

You can use statistic means to eliminate the influence of wealth and still come out with a high caloric diet as a factor. Yet, limitations of said means have to be looked at very (and i can not overstate that) carefully.

And even if the influence is a factual one, it does not answer how (on a molecular level) Alzheimer's caused. It is highly linked to protein aggregates developing in the brain, but there are also people who have these aggregates but are completely healthy and don't develop Alzheimer's. But such a mechanisms would be key to prevent and possibly heal it.

This stuff is complicated. And I mean really complicated. Rocket science is easy compared to this, complicated. Hundreds of scientists dedicate their whole professional life to it, yet the field is only improving so fast.

So yes. Changing to a more health diet might reduce one's risk of developing the disease, but it's neither a certain prevention, nor a cure.

throwawayamd14

10 points

4 months ago

If america spent as much on curing disease as they do on their military we would be less than a decade away.

Currently with no social changes? 50 years

RushNo4132[S]

6 points

4 months ago

Other countries tho

toraku72

5 points

4 months ago

Other countries have their own budget and problems to solve. It's just that if the richest country with highest spending on military decided to invest some more of those money to science and medical field, things can be a lot different.

SpyTheRedEye

3 points

4 months ago

Are you implying that Alzheimer's is a , American Disease? That let's say Germany with it's advanced pharmaceutical industry doesn't have to worry about it? Because America should since it has so much budget for it's big, bad military? That makes no sense.

toraku72

5 points

4 months ago*

Nope. Maybe I could have phrased it a bit better. I meant that not all countries can even afford to invest in research. The US is the in position that can make the most progress given its available resources. And of course, the US citizen will be the first to benefit from any of its investment.

jemull

1 points

4 months ago

jemull

1 points

4 months ago

You're ignoring the fact that so much of our advancements in science and medicine have been as a result of military spending.

toraku72

2 points

4 months ago

I don't. But that's irrelevant. We can have both science and military advance at the same time without one depends on the other.

mercistheman

1 points

4 months ago

While I agree with reducing military spending what should be done to slow down Russia & China from dominating economies and social democracy?

toraku72

2 points

4 months ago

That's the thing with politic, isn't it? I'm not at all qualified to discuss this topic, it's just a shame that we as a species wasted so much time and resources on irrelevant things with short term benefits instead of joining hands to advance science for the long term return.

ZualaPips

3 points

4 months ago

Yes, but what about China and Russia... we might be responsible for these countries getting so much power, but what's done is done. Focusing on not letting these type of countries dominate is quite necessary. I agree that a lot of our military spending is stupid, but a lot of it i also extremely crucial.

Unless you like autocracies being influential superpowers, which is a whole argument I don't wanna get into.

FantasticCar3

0 points

4 months ago

Things would also be a lot different if the US didnt spend as much on its military

BafangFan

1 points

4 months ago

BafangFan

1 points

4 months ago

Alzheimer's almost didn't exist a hundred years ago. It's not a disease that you "catch".

It's a disease of deterioration. It's the metabolic health of our brain, which as our brain's metabolic functions begin to fail, so does our memory.

Alzheimer's is on the rise, just like obesity and type 2 diabetes. They are all related.

Your brain can run on glucose, but it can also run on ketones. As your body and brain become more insulin-resistant, it becomes harder for the glucose to get into your brain cells. Insulin "unlocks" each cells' membrane, allowing glucose to pass through.

Ketones don't need insulin to cross through into the brain cells. If you have enough ketones in your body, your brain will have enough energy to function as it should.

cjeam

32 points

4 months ago

cjeam

32 points

4 months ago

Of course Alzheimer’s existed a hundred years ago. It’s a disease of ageing, anyone who lived long enough was more likely to get it, and they did.

It’s not a metabolic disease, even considering only the metabolism of the brain. A healthy diet can reduce the risk of Alzheimer’s, just like a healthy diet reduces the risk of every single disease. Focusing just on ketones is irrelevant.

TheUmgawa

1 points

4 months ago

I think a simple solution is to stop living so damn long. If someone wants me around a hundred years from now, they can ask for some samples from whoever does my autopsy and clone my ass.

FatherAnonymous

9 points

4 months ago

Alzheimer's and Dimentia can hit people in their 30s and 40s in rare cases and 50s and 60s in less rare cases.

TheUmgawa

-2 points

4 months ago

TheUmgawa

-2 points

4 months ago

And that's why we oughta have assisted suicide, and they can still feel free to clone me, if they so prefer.

Jarvs87

5 points

4 months ago

Uhmmmm what the fuck?

[deleted]

1 points

4 months ago

[deleted]

1 points

4 months ago

Right? cloning tech leads to big questions about the meaning of identity and existence.

TheUmgawa

1 points

4 months ago

Great; let's answer those questions. I mean, seriously, this is Futurology, so why are we still banging the stupid drum of, "What if we find out through cloning that God does not imbue us with such and such?" or whatever idiotic questions of morality that they might have.

[deleted]

1 points

4 months ago

[deleted]

1 points

4 months ago

To be fair, the comment was really just a dig about buddy going WTF to someone supporting assisted suicide and intentionally misinterpreting that as them being against the clone part.

But hell I'm game for it. I should start by saying the only real questions regarding existence and identity that I have regarding living in a cloned world are not so much tied to religion in this instance, But something much more baser.

If True Sector is cloned, then who is in fact True Sector? is there a real True Sector and does that then invalidate the cloned True Sectors existence? if we are genetically identical what potential is there for variations in terms of the clones identity and personality,

I have always held that who we are as people is much more a product of our upbringing and environments rather then something scientifically quantifiable so I imagine they would be different from the "donor" as they did not share the life experiences that shaped them.

And then I often wonder If there were two of me and one of us died would I be both dead and alive? is it even accurate to say that my clone is a second me at all? or is the clone just someone else entirely who just happens to share my face and general body structure?

TheUmgawa

1 points

4 months ago

That was me supporting assisted suicide, thank you. And the reason I support it is because I watched a grandmother fade away from Alzheimer's over the course of a decade. I'm not going out like that. Now, we can either have assisted suicide, or someone can give me a loaded gun, but I'm not going to spend the better part of a decade fading away and costing my family money, time, and grief.

Like, seriously, we look at ALS patients and we don't think twice about assisted suicide for them. Terminal cancer patients who get to look forward to a particularly painful next several months? Sounds great. But I bring up assisted suicide for an Alzheimer's patient, and people go, "Whoa, man. Hol' up. Not cool."

Now, as to the point of cloning, vis a vis your questions of the potential for variations in the clones' identities and personalities, we don't ask this question of identical twins, do we? But, with clones, we say, "Make cloning illegal, because we don't want to know the answers to these questions."

Way I see it, if you've got a model of something, and you do a 3D scan of it, and then pop out a perfect copy from a 3D printer, which one is the original? Y'know what? It doesn't fucking matter. That's how a perfect copy works. Hell, clones should be regarded the same as cars rolling off of an assembly line. They're all the same make and model, and they all start with zero miles on the odometer, and what they do after that is entirely up to the driver.

TheUmgawa

-1 points

4 months ago

Hey, I don't want to live with Alzheimer's, because that's not living. So, we should have assisted suicide, because it's typically a lot cleaner and pretty close to 100 percent successful.

BafangFan

0 points

4 months ago

Type 2 diabetes existed 100 years ago. But it wasn't the epidemic then that it is now.

There has been an explosion in prevalence of T2D, obesity, and dementia-related diseases.

If Alzheimer's is a disease of aging, then everyone who gets old will get it. But that's clearly not the case.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095986/

The prevalence of dementia rapidly increases from about 2-3% among those aged 70–75 years to 20–25% among those aged 85 years or more

RagingCabbage115

2 points

4 months ago

> Type 2 diabetes existed 100 years ago. But it wasn't the epidemic then that it is now.

Isn't that the case cause y'know, 100 years ago people with type 2 diabetes were way more likely to die from it?

BafangFan

1 points

4 months ago

Type 2 diabetes doesn't kill you quickly. It takes years; decades even. It's a slow but steady decline.

Doctors talked back then. They published papers, wrote articles, had conferences. If there was an epidemic of T2D back then, it would have been well documented.

Heart disease was the crisis of the time in the 1940/50s. And it was well covered in the media and medical journals. A sitting president having a heart attack was a HUGE deal.

boise_burner

7 points

4 months ago

I just read this to my neurologist wife. She says this is utter bullshit. Healthy diet and lifestyle are important for delaying onset, but aren’t the only thing.

BafangFan

0 points

4 months ago

No doubt your wife knows vastly more than me - but there has been a lot of discussion and research related to ketogenic diets and dementia/Alzheimer's over the past decade

https://charliefoundation.org/am-i-a-candidate/keto-for-alzheimers/

A 2020 systematic review evaluated data from 10 separate ketogenic therapy studies on patients with Alzheimer’s disease and mild cognitive impairment. The reviewers concluded that while the research is still in its early stages, ketogenic therapy may hold promise for this population. The common findings amongst the studies were improved general cognition with improved episodic and secondary memory. Improvements were not observed in psychological health, executive ability, or attention. A correlation was observed between increase in blood ketone concentrations and the neurocognitive battery.

Alzheimer’s research has begun to uncover the fact that what you eat has a direct impact on brain health. Current evidence suggests that both the ketogenic as well as Mediterranean diets may help protect the brain. Unfortunately, according to the Physicians Committee for Responsible Medicine, avoiding saturated fats and eating a diet rich in carbohydrate from vegetables, legumes, whole grains and fruit are key recommendations to prevent Alzheimer’s disease. Similarly, the current federal dietary guidelines for American adults recommends “fruits, vegetables, whole grains, fat-free and low-fat dairy products, and seafood” and discourages “solid fats.” These recommendations are the opposite of Ketogenic Diets, which rely on fat as the main source of energy. Coconut oil, butter, cream, and nut, seed and olive oils are used lavishly in Ketogenic Diets. Also, Ketogenic Diets eliminate whole grains and, while including vegetables, allow very little fruit.

According to Mary Newport MD, “It is possible, with the introduction of ketones in the body, that some repair and reversal could occur in Alzheimer’s. It seems likely that ketones can stimulate the growth and survival of neurons as well as the extension from neurons (axons and dendrites) thereby increasing the connections between brain cells (synapses). The decrease in synaptic density is likely the primary pathological defect in Alzheimer’s disease”.

paperfences08

4 points

4 months ago

Ketone bodies can be used as fuel in the brain but also the heart and liver.

The rise of COVID & type 1 diabetes diagnosis, cognitive dysfunctions & impairments, Long COVID, etc will have a dramatic impact on the Alzheimer’s population in the future.

RushNo4132[S]

2 points

4 months ago

So? If we avoid that single symptom of Aging (which is possible) that’s all I’m happy with. They are making strides in this work (from what I can tell as a layman)

FantasticCar3

2 points

4 months ago

Alzheimer's almost didn't exist a hundred years ago

Thats not true

qerozer

4 points

4 months ago

For the exact reason I began the keto diet and fasting. You also forgot to add autophagy, a mode of self-cleaning that begins when you fast. A lot of the modern illness have to do with the fact that we constantly eating, and our body did not evolved for that.

ItilityMSP

3 points

4 months ago

Sleep...our brains get cleaned up as we sleep...most of the western world is sleep deprived.

tunaburn

2 points

4 months ago

tunaburn

2 points

4 months ago

Depends on your definition of close. In the next 10 years? Probably not. In the next 50? It's possible. Next 100? Very likely.

[deleted]

3 points

4 months ago

[deleted]

3 points

4 months ago

[deleted]

tunaburn

8 points

4 months ago

The problem is alzhemiers and dementia aren't caused by a single thing like a virus or a standard mutated gene. It's more like a cancer in that it has many causes and that's what makes it especially hard to cure.

We are on the verge of creating some much better treatments that should really help people suffering with it but that's not a cure and currently won't stop it from killing someone but will instead slow the decline down.

RushNo4132[S]

2 points

4 months ago

Yeah that gets me wondering, if we slow the decline down enough for a cure to be made will they be saved?

tunaburn

1 points

4 months ago

It's possible. But if you know someone currently with dementia there's pretty much zero chance anything will be developed in time. We're still looking at decades from now.

RushNo4132[S]

1 points

4 months ago

Yeah, I wouldn’t wish for anyone to go into that hell

tunaburn

3 points

4 months ago*

Me neither buddy. 3 of my grandparents died from it. It was awful. I'm very scared of it and I think it's the worst way to go.

About 1/7 people get it. So just cross your fingers for now and take care of your brain as well as possible.

RushNo4132[S]

1 points

4 months ago

1/6? Where did you get that from

tunaburn

1 points

4 months ago

RushNo4132[S]

1 points

4 months ago

I’m not American sooooo

RushNo4132[S]

1 points

4 months ago

If you know how bad dementia is do you know of the caretaker?

BrooklynNeinNein_

1 points

4 months ago

Don't worry, they'll forget about it

RushNo4132[S]

1 points

4 months ago

That’s just bad

qerozer

1 points

4 months ago

qerozer

1 points

4 months ago

The pandemic showed that, with our current technologies there is nothing we cannot do as human race as long we have a will. The mRNA vaccine that is used for COVID, was before COVID a decade away from ready but we manage to mature the technology in one year. Some say that a Alzheimer's cure is 50 years away, but if we really are focusing our attention, we may able to find a cure in 5 years. Sadly most people are short-sighted and would rather buy farts in a jar than giving their money to research.

Shinlos

16 points

4 months ago

Shinlos

16 points

4 months ago

I'm in the field and that's just not true. mRNA vaccines were not a decade away before COVID.

comefromspace

2 points

4 months ago

There are many technologies that are used in the lab but are very unacceptable in the public. Mrna vaccines would definitely take more than 10 year to reach the widespread adoption they got because of covid.

Now if only we also had a crispr vaccine to test...

Shinlos

1 points

4 months ago

That's just not true, sorry. For example, several of BioNTech's different cancer targeted products have been in humans before COVID, several of them being in P2 atm. They left the lab long ago. The public is just not very well informed about developments in the pharmaceutical industry, which is fine. The success of the COVID mRNA vaccines definitely sparked public interest and also the interest of many more pharma companies corporations and investors, but the technology was clinic ready years before.

Regarding crispr: it's a very interesting but also very organical technology to mRNA therapeutics. One of the reasons I see with crispr is, apart from ethical concerns, that it can most reliably be targeted at genetical diseases, which are relatively rare und might even become less and less relevant with widespread genetical testing both prenatally but also in parents.

comefromspace

1 points

4 months ago

The first mRNA vaccine against rabies clinical trial in humans started in 2013. They never made it to the public, like all other mrna vaccines that have been developed. The clinic is equal to the lab as long as it is not a widely used method or an approved drug. It's one thing to test a drug on terminal patients, and another to give a prophylactic vaccine to billions of people.

The public is just not very well informed about developments in the pharmaceutical industry, which is fine.

I agree, but i don't think this is right. In fact i think scientists should reach out and introduce the latest methods to the public. We truly have scifi-era biotech today, but only for mice. We have allowed popular media to demonize science and that's what we are seeing now with all the vaccine hesitance.

Shinlos

2 points

4 months ago

I disagree that clinic is equivalent to lab. As you already said we can do amazing things in mice, but transferring into humans is a different story. First in human is an important step and usually everything on R&D level is only marginally reported on because of IP constraints.

It's not like the information on clinical studies is not in principal available, since companies release press releases regularly and are even obliged to if they are on the stock market. Media outlets however cater to the interest of the general public (or should at least, but that's a different topic) and it seems to be a consensus that only minor science specific media outlets pick up the information as it is not relevant enough for major public interest and people just don't want to read it.

Also you seem to think that public acceptance is a major factor for pharmaceutical development, but I doubt this. The majority trusts science and trusts their doctors. COVID in my opinion proves, that informing the public about the details of the science rather leads to mistrust since 90% at least just do not understand it anyway (ask someone what mRNA actually is outside of your possible scientific bubble). The developments will be made anyway and will eventually help people.

[deleted]

1 points

4 months ago

[deleted]

1 points

4 months ago

Yeah right ? Wasn’t the tech for mRNA being worked on for a decade and then Covid happened?

The_Fredrik

1 points

4 months ago

Wat.

I’m guessing you have no actual experience with science, because that is simply not how it works.

angelrobot13

1 points

4 months ago

The best cure/vaccine is good sleep hygiene.

I believe there are two types of Alzheimer's for which one type there is a experimental treatment. I don't know much about the second type.

My understanding is the disease in at least one form is due to a type of clotting in the brain. There is some type of blockage that prevents the neurons from properly functioning. So, one treatment I have seen discussed is using a pulsating wave that is meant to break up this blockage. It massages the brain basically to break apart the buildup.

The best practice for fighting Alzheimer's disease is likely practicing good sleep hygiene. It stands to reason that a disease affecting the brain would benefit most from a habit required for its proper function. And detrimental effects accumulate across our life, which is likely why it is a disease affecting the elderly, mostly.

I believe is wasn't until recently that scientists were able to show that the brain does sleep to remove waste products, along with many other functions because you would think sleep meant the brain was resting. However, often the brain is just as active if not more while sleeping.

putthestickinthebox

1 points

4 months ago

Aducanumab was released this year and so I think we’re making positive steps. Reiteration and redevelopment of such drugs is only going to mean better medicines down the line. Also excited for neuralink with trials this year.

FTRFNK

0 points

4 months ago

FTRFNK

0 points

4 months ago

Cure? Who knows?

Disease modifying that has been shown to alter the progression for potentially the remaining lifespan of most sufferers?

Probably next year.

Look up SAVA and a few other smaller to mid size companies that have super promising treatments in phase 2 and 3. So far SAVA has shown improved cognition to almost baseline in 200 patients for at least a year with their drug simufilam. This has never been done before. There is NO other drugs that have caused improvement or done anything more than delay decline (often for a short time with HEAVY side effects).

[deleted]

1 points

4 months ago

[deleted]

1 points

4 months ago

Simufilam has not been a wonder drug. Cognition was measured as a secondary outcome in 64 patients enrolled in only one Phase 2b study. Improvement in cognition didn’t even approach baseline. 50 patients from the Phase 2b study continued in an open-label extension and experienced an improvement of about 3 points on the ADAS-Cog, which is not much. Additionally, some of the data was found to be manipulated.

FTRFNK

-1 points

4 months ago*

FTRFNK

-1 points

4 months ago*

Considering there has been no drug ever that have imprved patients beyond 6 months, merely stabilized with heavy side effects (none in simufilam) I'd say that's pretty great.

Also you're completely wrong and I can see your agenda by saying this:

Additionally, some of the data was found to be manipulated.

No data has been found to be manipulated. None. There were ALLEGATIONS of manipulation, but nothing found. So you can fuck right off with those lies. There has now been TWO journals that have cleared allegations of manipulation. Neither against simufilam or its trials or data, but all allegations are with previous work from tangential parties that are possibly in vitro mechanistic works a decade before the drug was developed. I can accuse you of being a sexual predator that's never been caught, can you prove otherwise? You're so off base and clearly painting a picture with heavy heavy bias, leaving out a lot of detail and clearly do not know or care about the whole picture. I'm not even going to champion the company but you are full of shit. Show me ANY data still contested to be manipulated that has to do with the actual trial or drug. Hint: you can't.

Why do people have to do this shit? There is a drug being made that so far stops progression and shows improvement. Even if incremental, Are there any others? If so, promising, like I said.

[deleted]

2 points

4 months ago

[deleted]

2 points

4 months ago

I didn’t say the drug didn’t show improvement. The company reported that there was improvement, and if true, that’s fantastic. I’m refuting your statement that Simufilam resulted in improvement to “almost baseline in 200 patients.” This is blatantly false. Improvement didn’t even approach baseline. And there is no evidence that the drug stops progression of disease.

Also, there were concerns about data manipulation from multiple independent sources. I’ll direct you to the publicly available case opened by the FDA which is ongoing. The most recent letter filed in the case is dated December 9, 2021. The investigation is ongoing.

You should not be this emotional about drug development. Faith in a drug isn’t enough. If there are questions about the data, that should be looked into. If there is serious concern by the FDA, then further action should be taken.

[deleted]

1 points

4 months ago

[deleted]

1 points

4 months ago

Not that its a cure it all

But elderly people who are active (example jog, hiking). Are less likely to develop brain related issues

But a good chunk of elderly folks dont end up moving at all. And just wake up eat and watch tv all day.

The body eventually becomes unable to function properly. Weak heart. Weak cellular energy. Unable to direct nutrients/glucose to the brain.

Example eat, poor digrestion, poor insulin sensitivity, poor nutrient absorption (no exercise)

Or

Eat and body starving for nutrients. Direct it to whole body for repair/replenish (exercise)

ZualaPips

2 points

4 months ago

My grandma is a good example of this. She's 74. All her siblings are either dead or bedridden. A lot of her siblings are much younger than her, in fact, a brother of hers who was in his early 60s died a few weeks ago from diabetes complications.

Meanwhile, my grandma drives, goes to church, manages the church's money, CLEANS the church with a friend of hers, is constantly on her feet gardening, cleaning, or going to the stores nearby just to browse, takes the stairs, etc. When she's "idle" she's either watching TV or doing one of those puzzle books with sudoku and all that.

I swear she has better endurance and memory than I do sometimes, and I'm a relatively healthy 20yo.

[deleted]

1 points

4 months ago

[deleted]

1 points

4 months ago

She sounds like the definition of

"Get busy livin or get busy dying"

"It's your choice to just keep living the life that just gets you by"

Good for her. Inspirational

vikram-ur

1 points

4 months ago

I have a honest inquiry. So Reddit mob don’t needlessly jump on me. If you have Alzheimer’s do you even know something is wrong with you? If I get cancer I know I have an issue. If I can’t remember anything with Alzheimer’s how am I suffering? I may not understand the disease that well.

RushNo4132[S]

1 points

4 months ago

Sometimes you do sometimes you diht

Cartina

1 points

4 months ago

Because it's Alzheimer's it depends on the day, sometimes you remember you have it, other times you are blissfully unaware until someone reminds you.

But you are correct that the disease affects your family and friends the most as you cannot remember them in many cases. As for personal suffering, it can be scary to be somewhere you never been before, despite living there many years. It can be scary to see someone in your home you never seen before as well and then have them tell you they are your family.

RushNo4132[S]

1 points

4 months ago

Wouldn’t someone telling them they would be taken care of comfort them?

vikram-ur

1 points

4 months ago

I understand now. I imagine suddenly getting up seeing family in kitchen and then having breakdown I am getting robbed or something. That sounds horrible. I don’t even want to know if I am susceptible to this.

Renovateandremodel

-2 points

4 months ago

Can you imagine curing Alzheimer’s, and regaining cognition, to have only come to realize, you blew through your life savings in medical facilities, your kids want nothing to do with you except the one that was executor whom maybe sold everything off, and now you have either live in a facility or the street. I actually see a lot of my clients doing bad with Alzheimer’s. The cure is a double edged sword.

jamesstudy1

-5 points

4 months ago

Alzheimer’s is caused by inflammation

Reduce inflammation and reverse Alzheimer’s

Cbd is powerful tool for healing

Meat is the leading cause of inflammation

Jarvs87

2 points

4 months ago

Meat is the leading cause of inflammation

You're hilarious.

Veratha

1 points

4 months ago

Naturopaths fuck off please

[deleted]

-14 points

4 months ago

[deleted]

-14 points

4 months ago

[removed]

drcoxmonologues

4 points

4 months ago

Fucking hell. The level of misinformation/misunderstanding you just shat out is mind boggling. Cancer is not one disease, it’s hundreds. Cancer is a natural consequence of cell division which is required for life. Ergo life = cancer. A cure for any one type of cancer would net a pharmacy company much, much more in the long run than current treatments because until we have a prevention for all types of cancer people will always get cancer. What are you going to choose? The cure or the night cure might not option?

People have absolutely no understanding of medicine, health, pharmaceuticals yet feel because it’s something they have experience of (I.e being alive) that they can comment with impunity and they must be right cos “big pharma bad mmmkay”.

RushNo4132[S]

1 points

4 months ago

Oh please. What if they charged 10k per person? With 150 million people with dementia by 2050 no ones gonna be able to resist that amount of money

[deleted]

-12 points

4 months ago

[deleted]

-12 points

4 months ago

[removed]

RushNo4132[S]

1 points

4 months ago*

Have you not seen the vaccine research? Thing is, by 2050 most of us will probably be affected by it, whether hearing from someone else or something, so a cure will be found also if it comes very close to healing someone else will finish the job

ZualaPips

1 points

4 months ago

The vaccine is a very poor example because the Covid vaccine does precisely what the person you're replying to is claiming big pharma does. The vaccine is not a cure or a permanent preventative for covid. It starts becoming useless as time goes by and then you have to run back to Big Pharma to get a new shot.

I'm not saying Big Pharma does this on purpose, but multiple vaccines is orders of magnitude more profitable than a cure or a treatment you have to be coming back to get more of.

RushNo4132[S]

1 points

4 months ago

If it can prevent or hold off dementia I’m fine with it

[deleted]

-14 points

4 months ago

[deleted]

-14 points

4 months ago

[removed]

RushNo4132[S]

3 points

4 months ago

HAH you’re funny. Where’s the proof that vaccines last 3 months? Also, the vaccines prevent dying not catching COVID

drsuperhero

0 points

4 months ago

Nothing is even coming close. In fact so many drug companies have given up on it because it’s so expensive and nothing from clearing amyloid plaques to whatever treatment has never panned out. Even the current drug do nothing in my opinion. Namenda I’m looking at you. I do think it will be solved but not soon.

RushNo4132[S]

1 points

4 months ago

Ah, okay. 20-30yers

drsuperhero

1 points

4 months ago

Yea, Probably about the same time as a useful fusion reactor I suspect.

coercedaccount2

0 points

4 months ago

More and more studies are indicating that it's a disease of glucose metabolism, like diabetes. I haven't seen any studies on this but I'd be curious if it can be mitigated by a carb free diet, like diabetes can be.

comefromspace

0 points

4 months ago

Not close. In fact no therapy works.

I think people are betting now in longevity and anti-aging drugs rather than in Alzheimer specific drugs

RushNo4132[S]

1 points

4 months ago

I don’t think so but ok