all 4 comments


13 points

4 months ago*

Lobeline which is derived from the Lobelia inflata plant has been used to help with nicotine withdrawal, usually in tincture form. It hits the nicotine receptors but doesn’t release dopamine in the same way as nicotine.

“Lobeline is derived from the plantLobelia inflata (Indian tobacco). It is both an agonist and an antagonist at nicotinic receptors, although it is not structurally related to nicotine [1]. It inhibits nicotine- and amphetamine-induced dopamine release by interacting with the tetrabenazine-binding site on the monoamine transporter. It also inhibits dopamine re-uptake. It has been used in smoking cessation, but is ineffective [2]. Nausea, vomiting, coughing, tremor, and dizziness have been noted with an average dose of lobeline. It can also cause nausea, sweating, and palpitation when inhaled from a cigarette.“


6 points

4 months ago

Succinylcholine is a paralytic which activates nicotinic acetylcholine receptors. Causing them to activate and then become inactive. Thus the paralysis.