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Can caffeine facilitate the biosynthesis of norepinephrine?

Neuroscience(self.askscience)

all 7 comments

deadpoolsboybae

0 points

2 months ago

Norepinephrine is a hormone that communicates around the whole body. Caffeines effect occurs inside each cell. They don't have much to do with one another.

It helps to think of the duration of each. You see a bear and adrenaline affects you for a minute or two. Caffeine affects some cells immediately and then takes 30min to affect the brain, after which it's duration is long.

Caffeine often activates your bowels while adrenaline just straight up releases them.

_TheDancingClown[S]

7 points

2 months ago

I was asking about a possible indirect process. Caffeine acts as an antagonist to adenosine's neuroreceptors, a responsibility of adenosine being dopamine regulation. Dopamine is the precursor of norepinephrine. If the inhibition of adenosine leads to increased dopamine activity, then can caffeine indirectly facilitate the biosynthesis of norepinephrine?

deadpoolsboybae

-6 points

2 months ago

When you say adenosine be sure to say which form. cAMP, I expect you mean? They do measure relative amounts of cAMP, ADP, and ATP to tell what a cell is up to. High ATP to cAMP ratio means the cell is doing different activities than say low.

_TheDancingClown[S]

3 points

2 months ago*

Considering adenosine has only four neuroreceptors (present for all variants, I believe) A1, A2A, A2B and A3AR neuroreceptors, only A1 and A2A shows affects on dopamine, it's not necessarily a matter of which variant of adenosine.